Last updated: Thursday, 25, November, 2010
Key InformationAppropriate Tests

Type I cryoglobulinaemia.

Associated with:

Monoclonal cryoglobulins

They are monoclonal immunoglobulins which self aggregate via their Fc receptors.

Type II cryoglobulinaemia (mixed monoclonal).

Mixed cryoglobulins

These are usually composed of a monoclonal component (usually IgG, IgM or IgA) and a polyclonal component (mainly IgG).

Identification and quantitation of the cryoglobulin(s), Rheumatoid factor, complement components C3 and C4.

Rheumatoid factor is commonly positive, with reduced complement components C3 and C4.

Type III cryoglobulinaemia

Type III mixed cryoglobulinaemia – composed of polyclonal immunoglobulins of all isotypes.

Both type II and type III mixed cryoglobulinaemia may be associated with: