Diabetes insipidus

Last updated: Saturday, 27, November, 2010
CausesAppropriate Tests

In the appropriate clinical context, the diagnosis can be established from serum and urine osmolality and plasma antidiuretic hormone assay.

If necessary, a water deprivation test provides the definitive diagnosis, but it must be performed as a hospital procedure under medical supervision.

Electrolytes, creatinine, urea. Monitoring is best performed by measurement of urine volume.

Hypothalamic/pituitary (central)

Tumour (primary/metastatic)

Trauma

Granuloma

Pituitary ablation

Idiopathic

Nephrogenic

Congenital/familial

Drug-related, especially

  • Lithium therapy
  • Methoxyfluorane anaesthesia

Renal tubulo-interstitial disorders