Last updated: Saturday, 27, November, 2010
Disseminated intravascular coagulation or defibrination syndrome.
FBC, blood film, platelet count; thrombin time, fibrin degradation products, fibrinogen assay to establish diagnosis. Platelet count, APTT, PT, PT/INR, fibrinogen assay to monitor course and therapy.
NB. The quantitative (latex) D-diner test is used for detection of fibrin degradation products. Its use and interpretation must be differentiated from the sensitive qualititive D-diner used in evaluation of a possible DVT or PE.
|Acute severe DIC|
|See Peripartum bleeding under Pregnancy.|
Acute promyelocytic leukaemia
|See Acute leukaemia.|
Acute intravascular haemolysis, especially
See Immediate haemolytic reactions under Blood transfusion - transfusion reactions.
|Sub-acute/chronic DIC||See also Microangiopathic haemolysis.|
Advanced/metastatic carcinoma, especially
|Presence of DIC can often be predicted from the clinical context; confirmatory tests may not be required.|
Retained dead fetus
|Monitoring is important (platelet count, FDP, fibrinogen assay) until fetus delivered, as acute and severe DIC may develop.|