Essential thrombocythaemia
Last updated: Tuesday, 30, November, 2010
| Key Information | Appropriate Tests |
|---|---|
Essential thrombocythaemia is a myeloproliferative disorder in which the haemopoietic stem cell proliferation leads to a predominant increase in platelet numbers, usually with neutrophilia. Clinical history to exclude reactive thrombocytosis or hyposplenism & PRV+MRD , FBC, blood film, marrow aspirate and trephine biopsy ± chromosomes, erythropoitin, Jak2 (V64F) indicated. See also Myeloproliferative disorders | |
Features | |
Thrombocytosis ± giant platelets | |
Splenic infarction | |
Thrombosis (arterial and venous) | |
Bleeding, especially from | |
| Variable abnormalities of platelet function have been described. The bleeding time does not predict spontaneous or surgical bleeding. |
| See von Willebrand's disease (VWD)-acquired |
Disease progression or transformation | |
Uncommon ~5% in patients not exposed to alkylating agents. |