Jaundice

Last updated: Wednesday, 15, December, 2010
CausesAppropriate Tests

Bilirubin, GGT, ALP, AST, ALT, LD; FBC, blood film; protein (total), albumin.

Carotene if bilirubin normal.

Neonatal

Bilirubin (total, conjugated), albumin; FBC, blood film; direct antiglobulin test.

Unconjugated hyperbilirubinaemia

Physiological

Haemolysis

See Haemolysis – neonatal.

Drugs

Hypothyroidism

Haematoma resorption

Breast milk jaundice

Crigler-Najjar syndrome

Conjugated hyperbilirubinaemia

Neonatal Hepatitis, especially

  • Alpha-1-antitrypsin deficiency

See Alpha-1-antitrypsin - faeces and Alpha-1-antitrypsin - serum.

See Toxoplasma antibodies - serum.

See Syphilis antibody testing - serum or CSF.

See Cytomegalovirus (CMV) detection.

See Herpes simplex virus (HSV) antibodies - serum, CSF.

Neonatal sepsis

Biliary atresia

See Cholestasis.

Galactosaemia

Adult

Hepatocellular disease, especially

Hepatitis

Hepatic failure

Increased bilirubin production

Cholestasis

Haemolysis

Ineffective erythropoiesis

See Megaloblastic anaemia.

Haematoma resorption

Impaired bilirubin uptake or conjugation

Gilbert syndrome

Crigler-Najjar syndrome