Last updated: Tuesday, 03, August, 2010
FBC, blood film, (often pancytopenia; oval macrocytosis, neutrophil hypersegmentation), platelet count; folate - red cell; vitamin B12 assay, if indicated.
Bone marrow aspiration is only occasionally required for diagnosis and/or confirmation.
Review clinical findings to determine likely cause.
Extremes of age - especially premature infants.
Drugs (may impair folate absrption), especially;
Low serum folate but adequate RBC folate.