Graft versus host disease
Last updated: Friday, 03, December, 2010
Caused by donor-derived lymphocytes reacting against recipient tissues, usually following bone marrow transplantation.
These lymphocytes originate from the bone marrow graft, or from unirradiated blood products given post-transplant.
It has also been reported (rarely) after blood transfusion especially with directed (family) donation.
This occurs in immunocompetent subjects and usually follow an acute course.
Occurs up to 100 days following transplantation.
Skin biopsy (affected area).
Bilirubin, ALP, ALT, AST, GGT; liver biopsy if indicated.
Colorectal biopsy may be indicated.See Diarrhoea-chronic
FBC; bone marrow aspiration may be indicated.
Occurring more than 100 days after transplantation.
Skin biopsy (affected area) may be indicated.
Small bowel biopsy, if indicated.