Hypergammaglobulinaemia

Last updated: Monday, 13, December, 2010
CausesAppropriate Tests

The reference interval for gamma globulin varies with age and between racial groups.

See Table 2 Reference intervals for immunoglobulins G, A, M (g/L)

Protein (total), albumin; protein electrophoresis, immunoglobulins G, A, M; FBC, blood film; CRP.

Polyclonal

Chronic bacterial infection

Chronic liver disease, especially

 

See under Hepatitis

HIV infection

Systematic rheumatic disease, especially

Angioimmunoblastic lymphadenopathy

See under Immunoproliferative disorders

Tropical splenomegaly syndrome

Monoclonal

Paraproteinaemia

MGUS

See Monoclonal gammopathy of undetermined significance

Multiple myeloma

Chronic lymphoproliferative disorders

See Lymphoproliferative disorders

Reference:

Undas et al. Homocysteine and thrombosis: from basic science to clinical evidence, Thrombosis and Haemostasis 2005: 1994;907-915

Lewis et al. Meta-analysis of MTHFR 6770-*T polymorphism and coronary heart disease: dose totality of evidence support causal role for homocysteine and preventative potential of folate, BMJ 2005 ; 331: 1053 - 1056