Hypocalcaemia

Last updated: Tuesday, 14, December, 2010
CausesAppropriate Tests

Calcium (total); albumin, calcium (corrected), phosphate.

Calcium (ionised), if indicated. Hypocalcaemia is only significant clinically if ionised calcium is reduced.

Low total, corrected, and ionised calcium

Artefactual

Collection in EDTA, citrate or oxalate anticoagulant will result in a spurious reduction in calcium.

See Table 1.

Renal failure - chronic

Hypoparathyroidism

Vitamin D deficiency

See under Osteomalacia.

Hypomagnesaemia

Rhabdomyolysis

See under Myoglobinuria.
Low total calcium, normal corrected and ionised calcium

Hypoalbuminaemia

Normal total and corrected calcium, low ionised calcium

Hyperventilation