Leucoerythroblastic anaemia

Last updated: Friday, 17, December, 2010
CausesAppropriate Tests

Presence of nucleated red cells and early myeloid cells in association with anaemia.

See also Anaemia, Leukaemoid reaction, Neutrophilia, with early myeloid cells (blood film)

Review clinical findings, FBC, blood film, differential WCC, platelet count

See Table 4 Reference intervals for leucocyte differential counts

Bone marrow infiltration, especially

Bone marrow aspiration and trephine biopsy may be indicated.
  • Metastatic Carcinoma
Bone marrow examination is appropriate if the presence of metastatic disease is otherwise unclear, or if documentation is required.

Bone marrow aspirate and trephine.

Severe infection, especially

Osteopetrosis

Marked bone marrow response, especially

A picture similar to leucoerythroblastic anaemia may be seen acutely, but the cause is usually obvious from the clinical and other haematological features.
  • Severe trauma/shock, especially
    Acute blood loss.
  • Acute haemolysis
Haemolysis
  • Recovery from marrow suppression