Myelofibrosis

Last updated: Friday, 21, January, 2011
PresentationAppropriate Tests

Myelofibrosis is one of the myeloproliferative disorders (clonal stem cell disorders) in which increased marrow fibrosis is the dominant feature.

See also Myeloproliferative disorders

FBC, blood film, differential WCC (leucoerythroblastic anaemia, tear drop poikilocytes); bone marrow aspiration and trephine biopsy with cytogenetics. The Jak-2 mutation occurs in approx. 50% of patients with idiopathic myelofibrosis.

Splenomegaly

Hepatomegaly

Anaemia, especially

  • Bone marrow failure
    • Disease progression
    • Cytotoxic drugs
  • Hypersplenism

Bleeding, due to

Usually late in the course of the disease.

  • Platelet dysfunction

Platelet aggregation/platelet release reaction.