Last updated: Friday, 21, January, 2011
Myelofibrosis is one of the myeloproliferative disorders (clonal stem cell disorders) in which increased marrow fibrosis is the dominant feature.
See also Myeloproliferative disorders
FBC, blood film, differential WCC (leucoerythroblastic anaemia, tear drop poikilocytes); bone marrow aspiration and trephine biopsy with cytogenetics. The Jak-2 mutation occurs in approx. 50% of patients with idiopathic myelofibrosis.
Bleeding, due to
Usually late in the course of the disease.
Platelet aggregation/platelet release reaction.