Myeloproliferative disorders

Last updated: Thursday, 23, December, 2010
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A group of related, clonal, stem cell disorders characterised by excessive production of erythrocytes and/or granulocytes and/or platelets, increased bone marrow fibrosis, splenomegaly and, often, hyperuricaemia.

They all have the potential for transformation to acute leukaemia.

Myeloproliferative disorders have been subclassified by the World Health Organization as follows:

See also Chronic leukaemia

Chronic myeloid leukaemia (CML)

Polycythaemia rubra vera (PRV)

Essential thrombocythaemia (ET)

Myelofibrosis

Chronic eosinophilic leukaemia

Chronic neutrophilic leukaemia

Atypical chronic myeloid leukemia

Chronic myeloproliferative disease - unclassifiable