Last updated: Wednesday, 27, October, 2010
The classification of amyloidosis is complicated. There is some overlap in the list below:
The definitive test is the demonstration of amyloid in a tissue biopsy, using special stains, IF and EM.
Ideally, biopsy of an affected organ (eg liver, kidney) should be performed. If no specific site can be identified, colorectal biopsy or gingival biopsy may demonstrate amyloid. Further tests may assist in determining nature and cause: FBC, CRP or ESR, protein electrophoresis - serum, protein electrophoresis - urine; paraprotein typing - serum ; free light chains if an immunoglobulin origin is suspected; immunoglobulins G, A, M; bone marrow aspiration and trephine biopsy. Creatinine, urea, protein (urine) to assess renal involvement.
Serum free light chains
|See also Paraproteinaemia|
Amyloid A origin
Molecular genetic testing
Beta-2-microglobulin - serum.
Familial + Inherited
See under Dementia.
See under Thyroid nodule/cyst.