Pancytopenia

Last updated: Friday, 21, January, 2011
CausesAppropriate Tests

Review clinical findings. FBC, ANA, blood film, differential WCC.

Bone marrow aspiration and trephine biopsy if aetiology uncertain, or if confirmation required.

Bone marrow failure

Aplastic anaemia, especially

  • Cytotoxic drugs

Thiopurine methyltransferase.

  • Irradiation
  • Viral infections, especially
    • Parvovirus B19 infection
    • AIDS

Myelodysplasia

See Myelodysplastic syndromes - classification

Bone marrow infiltration

Disseminated carcinoma 

See also Leucoerythroblastic anaemia

Acute leukemia

Miliary tuberculosis

See Tuberculosis

Myelofibrosis

Lymphoma

Hairy cell leukaemia

Multiple myeloma

Lysosomal storage diseases

Gaucher disease 

Molecular genetics - genetic disorders.

Niemann Pick disease

Ineffective haemopoiesis, especially

Megaloblastic anaemia

Myelodysplasia

See Myelodysplastic syndromes - classification

Paroxysmal nocturnal haemoglobinuria

Hypersplenism

Immune

SLE

Drugs, especially

  • phenacetin
  • PAS
  • sulphonamides
  • quinicine