Renal tubular acidosis

Last updated: Friday, 28, January, 2011
Key InformationAppropriate Tests

Electrolytes; ammonium, pH - urine.

See also Acidosis - metabolic acidosis

Proximal 

Fractional excretion of bicarbonate.

Genetic, including

  • Fanconi syndrome
    • Cystinosis
    • Lowe syndrome

Amino acids, phosphate, glucose.

Heavy metal poisoning 

See Heavy metal exposure/toxicity

Associated with other disease

Multiple myeloma

Sjögren syndrome

Vitamin D deficiency 

See under Osteomalacia

Amyloidosis

Acetazolamide

Distal

Urine acidification test.

Genetic

Autoimmune

  • Autoimmune Hepatitis
See under Hepatitis - autoimmune
  • Primary biliary cirrhosis 

See under Cholestasis

Hepatic causes

Renal causes

  • Hypercalciuria/nephrocalcinosis 

Calcium - urine.

See Urinary tract calculi
  • Tubulo-interstitial nephropathy
See Renal tubulo-interstitial disorders
  • Obstructive uropathy
See Urinary tract obstruction
  • Renal transplant rejection
  • Hyperoxaluria

Other

  • Vitamin D intoxication

See under Hypercalcaemia

  • Sodium depletion with hypovolaemia

Sodium - urine.

See Hyponatraemia
  • Drug therapy, especially
    • Amphotericin B
    • Lithium
  • Idiopathic