Last updated: Thursday, 17, February, 2011
Diagnosis and classification of vasculitis is based on the findings at biopsy of the affected tissue/organ, together with the clinical picture and the results of antineutrophil cytoplasmic antibodies (ANCA).
Extent of disease is assessed by diagnostic imaging; creatinine - plasma, urea - plasma; ALP, AST, ALT, GGT.
Activity of disease is evaluated by CRP or ESR, occasionally complement components C3 and C4.
Investigation for the underlying cause may include rheumatoid factor, cryoglobulin, protein electrophoresis, antinuclear antibodies, hepatitis B virus testing, hepatitis C virus testing, and HIV testing.
Clinical assessment. Antineutrophil cytoplasmic antibodies and complement assist in the differentiation of polyarteritis nodosa, and other vasculitides, from ANCA positive vasculitides which involve a broader range of vessels.
Mucocutaneous lymph node syndrome (Kawasaki's dicease)
Small vessel, including leucocytoclastic
Drug reaction, especially
Connective tissue diseases, especially
|See also Glomerulonephritis|
Large vessel, especially
Giant cell arteritis
Thrombo-angiitis obliterans (Buerger's disease)