Vitamin B12 deficiency
Last updated: Thursday, 23, December, 2010
FBC, blood film, differential WCC, platelet count.
Bone marrow aspiration only occasionally required for diagnosis and/or confirmation.
Lack of intrinsic factor
|Intrinsic factor antibodies are specific but positive in only 60% of patients. Parietal cell antibodies have low specificity.|
|See also Blind loop syndrome, below.|
Competition for dietary B12
Absence of ileal receptors forintrinsic factor/B12
* Laurence Solomon: Blood 2005: 105(3), 978 - 985