Waldenstrom macroglobulinaemia (Lymphoplasmacytic Lymphoma)
Last updated: Thursday, 20, January, 2011
WM is an indolent lymphoid neoplasm, which occurs mainly in older patients.
It is characterised by an IgM paraprotein and a bone marrow infiltrate with monoclonal plasmacytoid lymphocytes.
Hyperviscosity and progressive bone marrow failure are common complications of WM.
FBC, blood film, differential WCC; ESR; bone marrow aspiration/trephine biopsy. Protein (total), albumin, protein electrophoresis, paraprotein quantitation and typing, immunoglobulins G, A, M; plasma viscosity (in advanced disease).
|Commonly due to bone marrow infiltration.|
|Paraproteins may inhibit platelet function and/or fibrin polymerisation (thrombin time).|