Parvovirus B19 infection
Last updated: Friday, 24, December, 2010
Parvovirus serotype B19 is responsible for clinically significant infections and sequelae - parvovirus B19 antibodies.
Patients with persistent B19 infections may not have antibodies; diagnosis of persistent infection requires virus detection in serum, cells or synovial fluid (research laboratories only).
Erythema infectiosum (Fifth disease)
Testing usually not necessary.
Pure red cell aplasia
FBC; bone marrow aspiration may be indicated.See Aplastic anaemia
Transient aplastic crisis
In patients with chronic haemolysis eg, sickle cell disorders, hereditary spherocytosis, thalassaemia.See Haemolysis
Transient erythroblastopenia of childhood
Chronic bone marrow aplasia
Parvovirus B19 can cause marrow aplasia in patients with immunodeficiency, especially in those with acute leukaemia (lymphoblastic), congenital immunodeficiency states, AIDS and post-organ transplantation.
FBC; bone marrow aspiration.