Parvovirus B19 infection
Last updated: Friday, 24, December, 2010
| Presentations | Appropriate Tests |
|---|---|
Parvovirus serotype B19 is responsible for clinically significant infections and sequelae - parvovirus B19 antibodies. Patients with persistent B19 infections may not have antibodies; diagnosis of persistent infection requires virus detection in serum, cells or synovial fluid (research laboratories only). | |
Erythema infectiosum (Fifth disease) | Testing usually not necessary. |
Subacute polyarthritis | |
Pure red cell aplasia | FBC; bone marrow aspiration may be indicated. See Aplastic anaemia |
Transient aplastic crisis | In patients with chronic haemolysis eg, sickle cell disorders, hereditary spherocytosis, thalassaemia. See Haemolysis |
Transient erythroblastopenia of childhood | |
Chronic bone marrow aplasia | Parvovirus B19 can cause marrow aplasia in patients with immunodeficiency, especially in those with acute leukaemia (lymphoblastic), congenital immunodeficiency states, AIDS and post-organ transplantation. See Immunodeficiency FBC; bone marrow aspiration. |