Pituitary hormone excess
Last updated: Saturday, 22, January, 2011
Increased levels of pituitary hormones may be the result of autonomous production by pituitary adenomas, release from inhibitory feedback mechanisms, or ectopic secretion.
One or more hormones may be increased and if there is a pituitary lesion, there may be associated deficiency of one or more hormones.
See also Pituitary/hypothalamic disorders.
Growth hormone excess
Acromegaly, gigantism (in childhood).
IGF-I; growth hormone suppression test.
Ectopic syndromes (rare)
Pancreatic islet cell tumour
See under Pancreatic neoplasm
Carcinoid tumour (lungs, adrenals)
Dexamethasone suppression test (overnight); cortisol (free) - urine.
Then, if indicated, dexamethasone suppression test (long) including ACTH.See Cushing's syndrome
Ectopic ACTH syndrome
Patients may have clinical features of Cushing's syndrome.
Patients are not Cushingoid. ACTH is the appropriate test.
Prolactin; repeat, if elevated, to document persistent elevation.See also Infertility
Other pituitary tumour
'Pituitary' Hyperthyroidism: TSH, thyroxine (free).See Hyperthyroidism
Pituitary T4 resistance
LH, FSH, alpha subunit, testosterone or oestradiol.
Ectopic syndromes, especially
Human chorionic gonadotrophin (beta subunit).
Alpha subunit excess
These patients do not present with clinical features of an endocrine disorder: alpha subunit.
Alpha subunit secreting tumours