Prothrombin gene mutation (G20210A)
Last updated: Saturday, 01, May, 2004
|Key Information||Appropriate Tests|
Testing is indicated in patients who have had venous thromboembolism where investigation for an underlying cause is appropriate.
A mutation in the prothrombin molecule (G20210A) which renders it resistant to cleavage by activated protein C resistance.
It occurs in ~ 5% of the Australian population in the heterozygous form and is associated with an increased risk of venous thromboembolism.