Sjogren syndrome

Last updated: Friday, 14, January, 2011
Key InformationAppropriate Tests

Diagnosis is based on a number of clinical, radiological and pathological criteria, including the presence of Extractable nuclear antibodies against Ro (SS-A) and La (SS-B) and the results of labial salivary gland biopsy.

Tests to detect complications include FBC; AST, ALT, ALP, albumin; protein electrophoresis, immunoglobulins G, A, M; cryoglobulins.

Presentations/Associations

Keratoconjunctivitis sicca

See also Sicca syndrome

Xerostomia

Connective tissue diseases

Lymphadenopathy

Lymph node biopsy if malignancy suspected.

Parotid enlargement

  • Parotitis
  • Lymphoma (non-Hodgkin's)

Tissue biopsy if malignancy suspected.

See Parotid swelling

Renal tubular acidosis

Primary biliary cirrhosis

Mitochondrial antibodies.

See under Cirrosis - cholestasis

Hashimoto thyroiditis

Thyroid antibodies, TSH.

See Hashimoto disease