Last updated: Saturday, 15, January, 2011
Essential thrombocythaemia is a myeloproliferative disorder in which the haemopoietic stem cell proliferation leads to a predominant increase in platelet numbers, usually with neutrophilia.
FBC, blood film; bone marrow aspiration and trephine biopsy.
JAK-2 mutation may be positive in 50% pts with ET.See also Myeloproliferative disorders
Thrombosis (arterial or venous)
May be from a local lesion.
Variable abnormalities of platelet function have been described. The bleeding time does not predict spontaneous or surgical bleeding and is not indicated.
Acquired von Willebrand's disease
Disease progression/transformation to