Thrombocythaemia (essential)

Last updated: Saturday, 15, January, 2011
PresentationAppropriate Tests

Essential thrombocythaemia is a myeloproliferative disorder in which the haemopoietic stem cell proliferation leads to a predominant increase in platelet numbers, usually with neutrophilia. 

FBC, blood film; bone marrow aspiration and trephine biopsy.

JAK-2 mutation may be positive in 50% pts with ET.

See also Myeloproliferative disorders

Thrombocytosis

Splenomegaly

  • Splenic infarction

Thrombosis (arterial or venous)

.

Bleeding

May be from a local lesion.

Platelet dysfunction

Variable abnormalities of platelet function have been described. The bleeding time does not predict spontaneous or surgical bleeding and is not indicated.

Acquired von Willebrand's disease

Thrombocytopenia

  • Cytotoxic therapy
  • Disease progression/transformation

Anaemia, especially

Disease progression/transformation to