Thrombophilia
Last updated: Thursday, 23, December, 2010
| Key Information | Appropriate Tests |
|---|---|
Congenital | Term used to indicate an increased risk of thrombosis. See blood abnormalities under Thrombosis, arterial and venous. Specific factor assays. |
Factor V Leiden mutation | |
Prothrombin gene mutation (G20210A) | |
Protein C, Protein S deficiency | |
Antithrombin deficiency | |
Activated protein C resistance | |
Elevated F VIII:C | |
Acquired causes | |
Underlying malignancy | May be occult. Particularly adenocarcinomas |
Pregnancy and exogenous oestrogens | |
Immobility, postoperative state, venous stasis | |
Cardiolipin antibodies | May be part of the antiphospholipid antibody syndrome |
Elevated homocysteine | This may be due to an underlying genetic lesion or reflect deficiency in folate, B12 and/or pyridoxine in the diet. Testing for the methyl tetra hydrofolate reductase mutation may be indicated. |
Lupus inhibitor | |