Breast lesion

Last updated: Saturday, 13, November, 2010
CausesAppropriate Tests

Clinical assessment and diagnostic imaging directs investigation.

Breast biopsy (FNAB, core biopsy and/or open biopsy) of breast lumps and mammographically detected impalpable lesions.

Cytology of nipple discharge or aspirated cyst fluid.

Breast neoplasm, including

  • Fibroadenoma
  • Phyllodes tumour
  • Ductal papilloma
  • Carcinoma

Estrogen and progesterone receptor immunohistochemistry and/or HER2 testing may assist with the selection of therapy.

Serum tumour markers are not useful for diagnosis or screening but may assist with monitoring disease progression - CA 15.3, MSA, CA 549 are of only limited value; carcinoembryonic antigen is occasionally useful.

  • Paget's disease (nipple)
See Paget's disease

Fibrocystic change/mammary dysplasia

Simple cyst

Other conditions

  • Breast abscess

See Abscess and Mastitis infectious

  • Fat necrosis
  • Silicone leak from implant

There is no evidence that silicone levels or silicone antibodies are predictive of any complication of breast implants.