Last updated: Saturday, 13, November, 2010
Clinical assessment and diagnostic imaging directs investigation.
Breast biopsy (FNAB, core biopsy and/or open biopsy) of breast lumps and mammographically detected impalpable lesions.
Cytology of nipple discharge or aspirated cyst fluid.
Breast neoplasm, including
Estrogen and progesterone receptor immunohistochemistry and/or HER2 testing may assist with the selection of therapy.
Serum tumour markers are not useful for diagnosis or screening but may assist with monitoring disease progression - CA 15.3, MSA, CA 549 are of only limited value; carcinoembryonic antigen is occasionally useful.
|See Paget's disease|
Fibrocystic change/mammary dysplasia
There is no evidence that silicone levels or silicone antibodies are predictive of any complication of breast implants.