Legionella sp antibodies - serum
Last updated: Tuesday, 07, August, 2007
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5-10 mL blood in plain tube, collected at onset of disease and 4-6 weeks later (convalescent).
Investigation of pneumonia.
Confirmation of legionella infection depends on detecting a four-fold increase in titre to ≥128. A single titre of ≥256 is suggestive of infection.
Polyvalent antiserum is used to detect antibodies to serogroups 1-6 of L. pneumophila.
Monovalent antisera are used to identify antibodies to other species, eg, L. longbeachae, L. micdadei.
Seroconversion may take up to 6 weeks. A convalescent sample is required for optimal diagnosis.
Murdoch DR. Clin Infect Dis 2003; 36: 64-69.
Waterer GW et al. Am J Med 2001; 110: 41-48.