Rickettsia sp antibodies

Last updated: Thursday, 25, March, 2004

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Item Process
Specimen

5-10 mL blood in plain tube. Acute and convalescent samples.

Method

IF.

Application

Confirmation of a clinical diagnosis of typhus (murine or scrub) or spotted fever (including Queensland tick typhus and Flinders Island spotted fever).

Interpretation

The diagnosis of rickettsial infection is confirmed by a four-fold rise in antibody titre between acute and convalescent samples.

The traditional Weil-Felix test, based on the pattern of serological reactions to Proteus sp, lacks sensitivity and specificity and is no longer recommended.

Reference

Graves SR. Pathology 1998; 30: 147-152.

Baird RW et al. J Clin Microbiol 1992; 30: 2896-2602.