Urease test - gastric or duodenal mucosa

Last updated: Friday, 19, March, 2004

MBS Online Search Page: Click here for details

Item Process
Specimen

Gastric or duodenal endoscopic biopsy.

Method

Bacterial urease is detected by a colour change when urea is hydrolysed to ammonia.

Application

Detection of Helicobacter pylori in gastric or duodenal mucosa.

Interpretation

Presence of urease activity is very suggestive of the presence of H. pylori, but this test is less sensitive than histology of gastric biopsy for the detection of H. pylori.

Reference

Dunn  BE et al. Clin Microbiol Rev 1997; 10: 720-741.