Corneal scrapings/biopsy

Last updated: Saturday, 03, April, 2004

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Item Process
Specimen

Scraping or biopsy from inflamed or ulcerated cornea, processed for microscopy and culture at bedside.

Method

Gram stain, DFA and/or PCR testing for chlamydia, culture for bacteria, chlamydia, fungi, viruses and amoebae. Histology and EM.

See also Chlamydia trachomatis detection.

Application

Diagnosis of cause of keratitis or corneal ulcer, especially if long standing.

Interpretation

The cause of keratitis or corneal ulcer can be established by demonstration of the organism involved (eg, Pseudomonas sp, herpes simplex, fungi, or acanthamoebae) in corneal tissue.

Reference

Wilhelmus K et al. In: Specter SC ed. Cumitech 13A  ASM Press 1994.