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Both tissue and virus samples may be examined by electron microscopy.
If electron microscopy studies are contemplated laboratory staff should be contacted.
Electron microscopy is useful for rapid viral identification and is important for typing glomerulonephritis.
In tumour diagnosis where results from morphology and antibody labelling are equivocal electron microscopy can provide useful additional diagnostic information.
For the other conditions such as metabolic inherited disorders, peripheral neuropathies, myopathies and primary ciliary dyskinesia, electron microscopy can provide a definitive diagnosis.
Requires experience, several of the important diagnostic text books are listed below.
Glauert AM ed. Practical Methods in Electron Microscopy. North Holland 1975.
Robards AW. Procedures in Electron Microscopy. Wiley 1993.
Dickerson GR. Diagnostic Electron Microscopy: a Text/atlas. Igalen-Shoin 1988.
Ghadially FN. Diagnostic Electron Microscopy of Tumours. Butterworths 1985.
Henderson DW et al. Ultrastructural Appearances of Tumours: Diagnosis and Classification of Human Neoplasia by Electron Microscopy. Churchill 1986.
Papadimitriou JM et al. Diagnostic Ultrastructure of Non-neoplastic Diseases. Churchill 1992.
Llombart-Bosch A ed. Semin Diagn Pathol 2003; 20: 1-81.