Cytochemistry - bone marrow or blood
Last updated: Thursday, 01, April, 2004
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Bone marrow aspirate and/or 5 mL blood in EDTA.
Appropriate cytochemical methods are selected by the pathologist on the basis of the haematological and clinical features.
Specific cytochemical methods available include acid phosphatase (± tartaric acid), specific and non-specific esterases, periodic acid-Schiff (PAS), Sudan black, myeloperoxidase, lysozyme.
Differentiation between the various acute leukaemias and between the lymphoproliferative disorders.
|Interpretation||Cytochemistry contributed to the classification of acute leukaemia and lymphoproliferative disorders. However, the use of immunoperoxidase stains and immunophenotyping studies have largely replaced the traditional cytochemistry techniques. |
See Cell Immunophenotyping.
|Reference||Scott CS ed. Leukaemia Cytochemistry - Principles and Practice. Horwood Ltd 1989.|