Haemoglobin F (HbF) - alkali denaturation
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5 mL blood in EDTA tube.
Lysate of washed red cells; HbF is resistant to denaturation at alkaline pH; HPLC.
| Reference Interval|
Diagnosis and characterisation of the thalassaemias.
Increased levels in ß thalassaemias (particularly ðß-thalassaemia) and hereditary persistence of fetal haemoglobin.
Normal levels in the a thalassaemias.
Working Party of the General Haematology Task Force of the British Committee for Standards in Haematology. Br J Haematol 1998; 101: 783-792.