Haemosiderin - urine
Last updated: Wednesday, 28, April, 2004
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| Item | Process |
|---|---|
| Specimen | Fresh, early morning urine sample. |
| Method | Iron stain of centrifuged deposit of urine. Microscopic examination for intracellular iron-containing granules. |
| Reference Interval | Not detected. |
| Application | Investigation of possible chronic intravascular haemolysis. |
| Interpretation | Haemoglobin in glomerular filtrate is reabsorbed by renal tubular cells and broken down to haemosiderin. Presence of haemosiderin in uroepithelial cells indicates chronic intravascular haemolysis. |
| Reference | Dacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995. |