Neutrophil function studies
Last updated: Monday, 29, May, 2006
Uncommonly used and only performed in specialised laboratories with prior arrangement.
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| Item | Process |
|---|---|
| Specimen | 10 - 30 mL heparinised blood (consult laboratory). |
| Method | Several methods including chemiluminescence, nitroblue tetrazolium, dihydrorhodamine. |
| Application | Test inidcator for: Investigation of recurrent pyogenic or fungal infections especially chest, skin and gingival infections. Diagnosis of chronic granulomatous disease(CGD) and other primary defects in neutrophil function. Detection of CGD carriers. |
| Interpretation | Impairment of phagocytosis indicates impairment of oxidative blast may indicate CGD or even rarer neutrophil disorder which may be primary or secondary to ongoing pyogenic infection. Specialised interpretation is required. |
| Reference | Coates TD et al. In: Rose NR et al eds. Manual of Clinical Laboratory Immunology. 4th ed. ASM Press 1992. |