Plasminogen

Last updated: Friday, 02, April, 2004

This assay is rarely performed and only in specialised laboratories.

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Item Process
Specimen

4.5 mL blood in 0.5 mL citrate.

Method

Functional or immunoassay.

Reference Interval

50-150%.

Application

Investigation of tendency to venous thromboembolism; recurrent, unexplained, or with positive family history.

Interpretation

Plasminogen levels are low in full-term infants and plasminogen may be undetectable in premature neonates.

Congenital deficiency has not been described. Inherited plasminogen variants are associated with an increased incidence of thrombosis.

Decreased levels may be found in liver disease. Increased levels occur in pregnancy, women on the oral contraceptive pill.

Levels increase with age and are higher in Africans than Caucasians.

Reference

Dacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995.