Pyruvate kinase - red cell
Last updated: Friday, 02, April, 2004
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| Item | Process |
|---|---|
| Specimen | 5 mL blood in ACD, lithium heparin, or EDTA tube. |
| Method | Washed red cells are lysed. Assay performed at 37°C and results expressed as enzyme activity per gram of haemoglobin. |
| Reference Interval | Check with laboratory. |
| Application | Investigation of non-spherocytic haemolytic anaemia. Specific enzyme assay confirms deficiency. |
| Interpretation | Low levels confirm red cell pyruvate kinase deficiency. |
| Reference | Valentine WN et al. Ann Intern Med 1985; 103: 245-248. |