Thrombin time

Last updated: Friday, 02, April, 2004

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Item Process
Specimen

4.5 mL blood added to 0.5mL citrate.

Method

Thrombin added to platelet-poor plasma at 37°C; the clotting time is recorded.

Reference Interval

Varies with laboratory and method. Typically 14-16 seconds.

Application

Investigation of possible acquired or inherited disorders of haemostasis.

Occasionally indicated in the investigation of unexplained thrombosis.

Interpretation

Prolonged in afibrinogenaemia, hypofibrinogenaemia, dysfibrinogenaemia. Prolonged by heparin (corrects with protamine), FDP, paraproteins (partial correction with protamine).

Reference

Chanarin I ed. Laboratory Haematology. Churchill Livingstone 1989.