Hepatitis C genotyping
Last updated: Tuesday, 23, March, 2004
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| Item | Process |
|---|---|
| Specimen | 5-10 mL blood in EDTA or citrate. |
| Method | Detection of subtype specific mutations (various methodologies) after amplification, amplification using subtype specific primers, nucleic acid sequencing of amplified product if required. |
| Application | Pre-treatment evaluation of patients being considered for antiviral therapy. |
| Interpretation | Genotyping, together with viral load, is used to determine the appropriate duration of therapy. Infection with genotypes 2 and 3 responds better to antivirals. |
| Reference | Rosenberg PM. Clin Infect Dis 2001; 33: 1728 -732. |