Pemphigus antibodies - serum
Last updated: Wednesday, 11, July, 2007
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| Item | Process |
|---|---|
| Specimen | 10 mL blood in plain tube. |
| Method | Indirect IF, Immunoassay. |
| Reference Interval | Method dependent. |
| Application | Diagnosis of bullous skin diseases. Differentiates pemphigus from pemphigoid. |
| Interpretation | Intercellular cement substance antibodies (also known as desmoglein antibodies) are specific for pemphigus. Titres correlate with disease activity and effect of treatment. Pemphigus-like antibodies occur in burns, drug reactions and other disorders with extensive skin damage. |
| Reference | Stanley J. J Exp Med 1995; 181: 1-4. Zagorodniuk, I. et al A comparison of anti-desmoglein antibodies and indirect immunofluorescence in the serodiagnosis of pemphigus vulgaris International Journal of Dermatology 2003; 44(7) 541 - 544 |