Adenosine deaminase - red cell

Last updated: Tuesday, 06, April, 2004

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Item Process

1 mL blood (or pleural fluid) in lithium heparin tube.



Reference Interval

Method dependent.


Diagnosis of severe combined immunodeficiency due to adenosine deaminase deficiency.

Analysis of pleural fliud may be useful in the diagnosis of tuberculosis effusions.


The test must not be done if the patient has had a recent transfusion as the levels may be normal due to the enzyme present in the donor red cells.

Patients with adenosine deaminase deficiency have very low levels.


Hirschorn R. Pediatr Res 1993; 33: 35-41.

Perez-Rodriguez E and Jimenez Castro D. Curr Opin Pulm Med 2000; 6(4): 259-266.