Adrenal antibodies - serum
Last updated: Monday, 12, June, 2006
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| Item | Process |
|---|---|
| Specimen | 5 mL blood in plain tube. |
| Method | Indirect IF with primate adrenal substrate. |
| Reference Interval | Qualitative test. Positive result is significant. |
| Application | To predict risk of adrenal failure in patients with polyglandular autoimmune syndrome type I. Occasionally used in diagnosis of autoimmune adrenal failure. |
| Interpretation | Adrenal antibodies are present in 70% of patients with autoimmune Addison's disease and in <5% of those with Addison’s disease due to other causes. May be present in patients with other autoimmune disease. |
| Reference | Betterle C et al. Endocr Rev 2002; 23(3): 327-364. |