Angiotensin converting enzyme (ACE) - serum

Last updated: Wednesday, 07, April, 2004

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Item Process

5 mL blood in plain tube.



Reference Interval

Method dependent, typically 12-40 U/L.


Limited role in the investigation and monitoring of sarcoidosis.


Increased levels are found in at least 80% of patients with lung or multisystem sarcoidosis, but the test is less sensitive when only one system, other than lung, is involved.

Increased levels are also found in patients with other granulomatous diseases eg, tuberculosis, leprosy, asbestosis and silicosis, and occasionally in those with diabetes mellitus, hyperthyroidism.

Low levels are found in patients taking ACE inhibitors or corticosteroids.


Muller BR. Ann Clin Biochem 2002; 39: 436-443.