Antidiuretic hormone (ADH) - plasma
Last updated: Wednesday, 07, April, 2004
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| Item | Process |
|---|---|
| Specimen | 5 mL blood in EDTA tube. The tube should be pre-cooled and delivered to the laboratory on melting ice, for immediate separation at 4°C and freezing. |
| Method | Immunoassay. |
| Reference Interval | Depends on plasma osmolality and intravascular volume. |
| Application | The test may be used, in conjunction with plasma osmolality, to distinguish between central and nephrogenic diabetes insipidus. |
| Interpretation | Central diabetes insipidus is associated with low ADH levels, regardless of plasma osmolality. Nephrogenic diabetes inspidus is associated with increasing levels of ADH as plasma osmolality increases. |
| Reference | Janicic N and Verbalis JG. Metab Clin North Am 2003; 32(2): 459-481. |