Clonazepam - plasma or serum
Last updated: Tuesday, 30, March, 2004
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| Item | Process |
|---|---|
| Specimen | 5 mL blood in lithium heparin or plain tube. The specimen should be taken at least four hours after the last dose. |
| Method | HPLC. |
| Therapeutic Interval | 50-160 nmol/L (15-50 µg/L). |
| Application | Monitoring clonazepam therapy. |
| Interpretation | The drug has a half-life of approximately 40 hours. |
| Reference | Nanda RN et al. J Neurol Neurosurg Psychiatry 1977; 40: 538-543. Epilepsia. 2000; 41:8 6-15. Review. |