Collagen crosslink fragments - urine

Last updated: Monday, 06, August, 2007

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Item Process

24 hour urine, random urine.


HPLC, immunoassay.

Results on random urine are expressed as a ratio with creatinine.

Reference Interval

Depends on method.


Diagnosis and monitoring of conditions with increased bone collagen breakdown, especially monitoring of treatment in patients with post­menopausal osteoporosis.


Deoxypyridinoline is specific for bone collagen. Pyridinoline can be derived from bone or tooth.

If excretion is increased it indicates an increase of bone breakdown.


Hannon RA and Eastell R. J Br Menopause Soc 2003; 9(1): 10-15.