Collagen crosslink fragments - urine
Last updated: Monday, 06, August, 2007
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| Item | Process |
|---|---|
| Specimen | 24 hour urine, random urine. |
| Method | HPLC, immunoassay. Results on random urine are expressed as a ratio with creatinine. |
| Reference Interval | Depends on method. |
| Application | Diagnosis and monitoring of conditions with increased bone collagen breakdown, especially monitoring of treatment in patients with postmenopausal osteoporosis. |
| Interpretation | Deoxypyridinoline is specific for bone collagen. Pyridinoline can be derived from bone or tooth. If excretion is increased it indicates an increase of bone breakdown. |
| Reference | Hannon RA and Eastell R. J Br Menopause Soc 2003; 9(1): 10-15. |