Cortisol (free) - urine

Last updated: Saturday, 27, March, 2004

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Item Process
Specimen

24 hour urine collection. Incomplete collection will give misleading results.

Method

Immunoassay.

Reference Interval

100-300 nmol/24 hours.

Application

Diagnosis of adrenocortical hyperfunction as an indicator of adrenocortical activity in the dexamethasone suppression test (long).

Interpretation

Increased excretion occurs with primary or secondary adrenocortical hyperfunction, although increased levels may also be seen in obesity, stress, depression and alcoholism.

The test is not used to evaluate adrenal hypofunction. The Synacthen stimulation test is a more appropriate approach in this circumstance.

Reference

Arnaldi G et al. J Clin Endocrinol Metab 2003; 88(12): 5593-5602.