C3 Nephritic factor (C3 NeF) - serum

Last updated: Thursday, 08, April, 2004

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Item Process
Specimen

10 mL blood in plain tube. The specimen should be placed on melting ice and transported immediately to the laboratory.

Method

Immunoassay.

Reference Interval

Qualitative test.

Application

Levels of C3 and C4 should be determined before this test is requested; see Complement components C3 and C4 - serum.

C3 NeF should only be requested when C3 levels are significantly reduced and C4 is normal, indicating alternative pathway activation.

Limited application in distinguishing types of mesangiocapillary glomerulonephritis.

C3 NeF is also present in partial lipodystrophy.

Interpretation

C3 NeF is detected in type II mesangiocapillary glomerulonephritis and in patients with partial lipodystrophy.

Reference

Garg A. Am J Med 2000; 108(2): 143-152.