Globulins - serum

Last updated: Thursday, 25, March, 2004

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Item Process

5 mL blood in plain tube.


Calculated: globulin = total protein - albumin.

Reference Interval

Neonate: 12-36 g/L
Adult: 25-35 g/L.


Identification of hypo- and hyper-gammaglobulinaemia.

Paraproteinaemias are not reliably detected by calculation of total globulin.

Specific measurement of immunoglobulins and protein electrophoresis is preferred.


Reference values may differ between racial groups.

Levels are increased with chronic inflammation, infection, autoimmune disease, liver disease, and paraproteinaemia.

Levels are decreased in protein-losing enteropathy, humoral immunodeficiency and sometimes in the nephrotic syndrome.

ReferenceSilverman LM and Christenson RH. In: Burtis CA and Ashwood ER eds. Tietz Textbook of Clinical Chemistry. 2nd ed. WB Saunders 1994.