Globulins - serum

Last updated: Thursday, 25, March, 2004

MBS Online Search Page: Click here for details

Item Process
Specimen

5 mL blood in plain tube.

Method

Calculated: globulin = total protein - albumin.

Reference Interval

Neonate: 12-36 g/L
Adult: 25-35 g/L.

Application

Identification of hypo- and hyper-gammaglobulinaemia.

Paraproteinaemias are not reliably detected by calculation of total globulin.

Specific measurement of immunoglobulins and protein electrophoresis is preferred.

Interpretation

Reference values may differ between racial groups.

Levels are increased with chronic inflammation, infection, autoimmune disease, liver disease, and paraproteinaemia.

Levels are decreased in protein-losing enteropathy, humoral immunodeficiency and sometimes in the nephrotic syndrome.

ReferenceSilverman LM and Christenson RH. In: Burtis CA and Ashwood ER eds. Tietz Textbook of Clinical Chemistry. 2nd ed. WB Saunders 1994.